Ivanno Jeremiah as Max, Leo Elster's conscious synth and confidant, built by David Elster to be a brother to Leo.

Jill Halfpenny as Jill Drummond (series 1), Pete's disabled wife.

He bought Anita because he felt Laura's absence caused a void, and he needed help managing their family.

Tom Goodman-Hill as Joe Hawkins, Laura's husband.

Millican is frustrated with her relentlessly officious and domineering manner, and generally refuses her help.

Rebecca Front as Vera (series 1), a medical synth from the NHS who is supposed to replace Odi as George Millican's caregiver.

He has gone missing between the first and second series, although Max believes that he is safe. Professor Hobb likens Fred to the Mona Lisa in terms of the complexity of his design.

Sope Dirisu as Fred (series 1), a conscious synth built by David Elster to be a brother to Leo.Pete is dissatisfied with Simon, thinking that he is his replacement. Jack Derges as Simon (series 1), Jill Drummond's attractive synth caregiver and physiotherapist.She names the new family synth Anita after a friend of hers who has moved away, and develops a strong affection for the synth. Pixie Davies as Sophie Hawkins, Laura and Joe's younger daughter.By the second series, she has begun working in a café, and is romantically interested in her employer. She was sold as new, but is actually Mia, a conscious synth built by David Elster to be Leo's babysitter, kidnapped and hacked with new software. Gemma Chan as Anita Hawkins / Mia Elster, a servile synth belonging to the Hawkins family.She is skilled in computer programming and hacking. Despite her own intelligence, she feels useless, claiming that synths will soon be able to do anything she can do. Lucy Carless as Mattie Hawkins, Laura and Joe's teenage daughter, who is upset that her family is falling apart and angry at the emerging role of synths in society.By the second series, she has become more accepting of her status and is in a relationship with Pete. Karen wants to end her life but her programming forbids suicide. Those around her have not discovered that she is a conscious synth and was created by David Elster to replace his deceased wife, Beatrice. Ruth Bradley as Karen Voss, a detective inspector and the partner of Detective Sergeant Pete Drummond.

At the end of the third series, Niska meets V, originally Odi, who tells her she is unique and has great power. In the third series, after Astrid is injured in a terrorist attack, Niska spends the series looking for revenge for her girlfriend. After a whirlwind relationship with Astrid, Niska returns to the Hawkins and asks to be tried as a human for her crimes. In the second series, she uploads the consciousness program to the synth network, but only a few synths are successfully upgraded. She is violent and resentful of humans and wishes to live her own life, but later starts to care about humans. Emily Berrington as Niska Elster, a conscious synth built by David Elster to be Leo's sister, assigned to work as a prostitute when they were separated.It explores a number of science fiction themes, including artificial intelligence, consciousness, human-robot interaction, superintelligence, mind uploading and the laws of robotics. The series focuses on the social, cultural, and psychological impact of the invention of anthropomorphic robots called 'synths'.

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